Reply from Dubgen:
The 4 -1 has 4 pipes that run into the collector, then a single pipe that runs down the car into the various back boxes etch.
The 4 - 2 - 1 runs 4 pipes from the manifold a short distance to a collector then 2 pipes to a 2nd collector (like a standard MKII GTI system) and finally 2 into 1 that runs down the centre of the car etc.
I think that the principal of the 4-2-1 is that gas flow is slightly greater than the 4-1.